The 26-year-old beauty is reportedly tired of her on/off boyfriend's ''immature'' ways and thinks he is ruining his life by putting partying ahead of making music.
A source told TMZ: ''Chris acts immature, like a child.''
According to the website, the final straw for Karrueche was when the 'Yeah 3x' hitmaker liked two fan photos on Instagram of himself and ex-girlfriend Rihanna - who he has been frequently re-linked with during his off periods with the model - together.
In response to the split, Chris has jetted off to St. Tropez on holiday - and took a good friend of his former lover with him in a bid to make her jealous.
However, far from getting the reaction he wanted, Karrueche has now changed her phone number so the 25-year-old singer is unable to contact her.
In a recent interview, Karrueche recently admitted Rihanna had caused problems with her relationship with Chris because her many fans have opinions about the situation.
She said: ''In this case my boyfriend is a celebrity whose ex-girlfriend is an even bigger [celebrity]...so, I'm not only am I fighting a battle with her, I'm fighting a battle with her 14 million fans or however else.
''So, imagine how that feels for me when I gotta get on Twitter and I see a whole bunch of stuff...they make up all kinds of crazy stuff and it's like they know nothing about me.
''But, you know, because they know nothing about me, because I stay so mute sometimes, that leaves open space for them to say whatever they want.''
'Smalls Change (Meditations Upon Ageing)' arrives in April.
The two awards have made for a great 72nd birthday present for the country music icon.