Rapper Jay will make his only European appearance of 2013 when he performs at the event, to be held at the Queen Elizabeth Olympic Park in London on July 12 and 13.
Promoter Steve Homer from Live Nation said: ''Wireless Festival has gone from strength to strength since its inception in 2005, we're incredibly excited to take it to its new home, London's iconic Queen Elizabeth Olympic Park, and are delighted to secure Justin Timberlake and welcome back Jay-Z.''
Justin has marked his return to music in 2013 after taking time off to concentrate on his acting career, recently unveiling tracks from his forthcoming third album, 'The 20/20 Experience'.
Jay has also been helping out with Justin's comeback, appearing on the album's first single 'Suit and Tie', which they performed at the Grammy awards together earlier this month.
Tickets for Wireless festival are available from Friday February 22 at 9am form www.wirelessfestival.co.uk.