The 'Baby' hitmaker - who recently crossed paths with the brunette beauty at Radio One's Big Weekend in Bangor, Wales - was overheard telling friends backstage he thought the pop star beauty was attractive and has hinted he wants to date her.
He tweeted: "Just did an interview where they asked me if there was anyone I wanted to work with from the show's line-up. I said Cheryl Cole. of course.
"I mean I heard Cheryl just became single. I mean aw c'mon!! Haha. What's up Cheryl?"
However, it would appear the 16-year-old pop star's hopes for romance with the 'Fight For this Love' singer - who recently filed for divorce from her ex-husband Chelsea soccer star Ashley Cole amid rumours of his infidelities - were short-lived, as 'Mean Girls' actress Lindsay Lohan warned Justin the singer is too mature for him.
She tweeted: "She is too old for you! Be wise Young Buck."
Justin recently revealed he prefers natural women than those who pile on lots of make-up in the hope of grabbing his attention.
He said: "I don't like girls who wear lots of make-up and you can't see their face. Some girls are beautiful but insecure and look much better without the make-up, but decide to put loads on.
"I like girls with nice eyes and a nice smile."