The film - about a perfect 1950s housewife dealing with her feelings for a black gardener and a homosexual husband - picked up five awards at the 18th annual prize giving, honouring indie movies.
The film itself triumphed over The Good Girl, SECRETARY, TULLY and LOVELY + AMAZING to pick up Best Picture.
The evening took on a musical note with Thora Birch, Jennifer Tilly, Illeana Douglas and Lesley Ann Warren agreeing to sing tributes to the Best Picture nominees, and they invited guests to sing along as a bouncing ball followed the words to the comical tunes on a big screen.
The full list of winners is as follows:
Best Feature: FAR FROM HEAVEN
Best Screenplay: Mike White (THE GOOD GIRL)
Best Cinematography: EDWARD LACHMAN (FAR FROM HEAVEN)
Best First Feature: Peter Care (THE DANGEROUS LIVES OF ALTAR BOYS)
Best Female Lead: JULIANNE MOORE (FAR FROM HEAVEN)
Best Male Lead: Derek Luke (THE ANTWONE FISHER STORY)
Best Supporting Female: Emily Mortimer (LOVELY + AMAZING)
Best Supporting Male: DENNIS QUAID (FAR FROM HEAVEN)
Best Foreign Film: Y Tu Mama Tambien
Best Foreign Film: Y TU MAMA TAMBIEN
Best Documentary: Bowling For Columbine (KL/WN/TN)
Best Documentary: BOWLING FOR COLUMBINE