Dench picked up the International Actress trophy for her turn in Philomena, in which she played an Irish woman searching for her adopted son, while Ejiofor scooped the male equivalent for his stellar performance in 12 Years A Slave.
Native Irish winners at the ceremony in Dublin included Brendan Gleeson, who won the Actor in a Lead Role Film award for his turn in Calvary, and Saoirse Ronan, who was named Actress in a Lead Role for Byzantium. Michael Fassbender (12 Years A Slave) and Sinead Cusack (The Sea) were honoured with Supporting Role trophies.
Calvary, about a priest who is threatened during confession, was named Best Film.
In Tv categories, creepy serial killer series The Fall was named Best Drama and its star, Jamie Dornan, won the prize for Actor in a Leading Role Television.