The '99 Problems' rapper admitted it is "blasphemy" to compare the 'Single Ladies' hitmaker to the 'Beat It' singer - who passed away from acute Propofol intoxication in June 2009, aged 50 - but he has been educated in similar ways by both of them.
Speaking on Miami radio station 99 Jamz, he said: "What I've learnt from her is similar to what I learnt from [Michael Jackson] - and I know that's blasphemy to compare the two because Mike was such an innovator, but I think she's like the second coming."
Jay also explained Beyonce - whom he married in 2008 - is like a "machine" in terms of making music, which inspires him to keep creating albums.
He added: "The hard work and dedication that she puts into her shows, it just makes you want to work harder at your own craft. She's like a machine."
The 41-year-old hip-hop star was recently approached to join the 'Michael Forever' tribute concert, which is due to take place at the Millenium Stadium in Cardiff, Wales, on October 8.
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