The True Lies star was not amused by MACFarlane as he took charge of Hollywood's biggest stage on 24 February (13), and just days after officials at the Parents Television Council called on Oscars bosses to make sure the funnyman is never invited back, the actress has taken aim at him in a Huffington Post article.
Curtis admits she was particularly turned off by the host's cheeky We Saw Your Boobs song, in which he poked fun at past and present Best Actress Oscar winners for baring their breasts on film.
In her column for the Huffington Post, she writes, "As an Academy member, as the child of former Academy members and as a woman, I expected more from the best that the movie business has to offer. The Oscars are about honoring art and artists.
"The 'boob' song, as it will be known in perpetuity, may go down as the highest-rated Oscar number in history, but at what cost? I'm sure public executions would get big ratings too, but is that what the Oscars are truly about? Ratings? When did they turn into a 'roast'?
"At least at a roast you know what's in store. What if actors and actresses stopped attending the Oscars because it was deemed open session to ridicule and parody them? Would the Academy be so cavalier then?
"What we will be talking about is Seth's lack of class and a 14-year-old boy's derogatory word for one of the most beautiful, motherly and literally nurturing parts of the female form."
Jane Fonda was another star upset by MACFarlane's jokes. She took to her blog to note, "What I really didn't like was the song and dance number about seeing actress' boobs. I agree with someone who said, 'If they want to stoop to that, why not list all the penises we've seen?'"
But the funnyman, who has stated he will never return to the Oscars stage as host, has his celebrity fans too.
Halle Berry, who was name-checked in his We Saw Your Boobs song, says, "He did what he wanted to do. That's his brand of comedy and people will love it and they will hate it. I thoroughly enjoyed the show... It takes so much to offend me these days after all the things that have been said about me, to me, so I didn't feel offended by that boob song."