The Wedding Crashers star scaled back on her career to care for her young daughters - Olive, five, and two-year-old Elula - but she has returned to the spotlight with two new films, Now You See Me and The Great Gatsby.
With her career now back on track, the Australian beauty has ruled out co-starring in a movie with her husband as they have their hands full raising their kids.
She tells Entertainment Tonight, "Personally, I think we collaborate on enough behind closed doors. We're working on some really important collaborations (our daughters), and I think that's more important.
"It's not like you're taking a break and looking on IMDbPro (website) to see your StarMeter falling. You're doing the most important, incredible thing. When you come back in, the perspective has changed. I truly believe you can't have it all and you shouldn't want to."
Fisher admits she still admires the comic's work, adding, "Obviously, I'm a big fan of his. My favourite movie will always be Bruno, and my favourite line will always be when he looks up at the sky and goes, 'So many stars in the sky. Makes you think of all the hot guys in the world.' So freaking random and funny."