Just two weeks after it emerged the Man of Steel hunk was dating the blonde actress, sources tell E! News the couple's fling is now over.
It is unclear why they have called time on their relationship, but the split is reported to be amicable.
During their short-lived romance, the pair was photographed hiking together and holding hands outside a supermarket in Los Angeles.
Cavill previously dated Fast & Furious 6 star Gina Carano, while The Big Bang Theory's Cuoco was briefly engaged to rocker Josh Resnik.