The pretty Iron Man star, 40, once tried out the wrinkle-smoothing jabs in a bid to stave off the ageing process, but admits she wasn't a fan of the treatment as she prefers a more natural appearance.
She tells Harper's Bazaar magazine, "I've probably tried everything. I would be scared to go under the knife, but you know, talk to me when I'm 50. I'll try anything. Except I won't do Botox again, because I looked crazy. I looked like Joan Rivers!"
The Oscar winner also reveals she has learned to ignore critics' opinions of her looks after adopting a new laid-back approach to life from her rapper pal Jay Z.
She adds, "I don't hold on to fear as much as I used to, because I've learned a lot about genuinely not caring what strangers think about me. It's very liberating. It's very empowering, and I've learned a lot of that from Jay - Shawn Carter - Z, because his approach to life is very internal. It's a very good lesson to learn."