Green Day were the first winners of the night, taking Best Album for AMERICAN IDIOT and Best Rock, while Chris Martin's band picked up Best Song for SPEED OF SOUND and Best UK + Ireland act.
Green Day and Coldplay were among the many acts who performed at Lisbon's Pavilhao Atlantico, including Pussycat Dolls, Akon, Robbie Williams, THE Black Eyed Peas, Foo Fighters, Shakira, Gorillaz and System Of A Down.
GORILLAZ provided the big shock of the night by triumphing over U2, Coldplay, Green Day and The Black Eyed Peas to garner Best Group, while Stefani went home empty-handed, despite lead the nominations in four categories.
Meanwhile, Live 8 organiser SIR Bob Geldof's tireless campaigning against poverty in Africa was recognised with the Free Your Mind award.
The main list of winners are:
Best Album: GREEN DAY - AMERICAN IDIOT
Best Song: COLDPLAY - SPEED OF SOUND
Best Video: THE CHEMICAL BROTHERS - BELIEVE
Best Group: GORILLAZ
Best Male: ROBBIE WILLIAMS
Best Female: SHAKIRA
Best New Act: James Blunt
Best Pop: BLACK EYED PEAS
Best Rock: GREEN DAY
Best Alternative: SYSTEM OF A DOWN
Best R+B: ALICIA KEYS
Best Hip-Hop: Snoop Dogg
Best UK + Ireland Act: COLDPLAY.