The actor wrapped a 10-season run as Joey Tribbiani on the hit sitcom, but immediately signed up for a spin-off titled Joey, which was critically panned and subsequently cancelled in 2006 after just two seasons.
In an interview with the U.K.'s Daily Telegraph, LeBlanc admits the high expectations to continue the legacy of Friends was too much to handle on his own.
He explains, "It was a dark time. The show had an unfair amount of pressure on it. It was meant to fill the shoes of Friends. But when you have six pairs of feet, and you take away five, it's harder to walk."
In addition, LeBlanc was also dealing with troubles in his personal life the same year Joey was cancelled, as he officially split from ex-wife Melissa MCKnight, and their daughter, Marina, was diagnosed with a with a form of dysplasia, a brain disorder that affects neurological functions, at just eight months old.
He continues, "I didn't feel like being funny. I had a lot going on in my personal life... I don't know if my marriage was doomed to fail. It was a great relationship once. Maybe it was my daughter's diagnosis. Maybe I got lost, focused on my work too much."