The In Da Club hitmaker has had a storied history with Stoute, who signed the then-rising rapper to his first deal at Columbia Records in 1999, but then declined to sign him a second time when he moved to Interscope Records.
50 was on the verge of closing a joint deal with Dr. Dre's Aftermath and Eminem's Shady Record labels in 2002, when Stoute intervened and encouraged the rapper not to sign with Eminem, telling the hip-hop star it would be the worst business decision of his life.
In an interview with MTV, 50 recalls Stoute confronting him in a Los Angeles hotel lobby and saying "'Don't do the deal with the white boy. Your s**t is serious.
"At the time, Em was doing Purple Pills with D12, so he's (Stoute) thinking Eminem's a joke. Of course, I did the deal with the white boy because Em is the only one that showed interest in me. He's my favourite white boy."
Stoute recently stirred up the feud between himself and 50 Cent when he called the rapper a has-been in a recent Vh1 documentary.