The Magic Mike star has teamed up with officials at youth empowerment organisation buildOn to provide kids in one community in the South Asian country access to education.
However, she needs the support of generous fans to help her reach her goal of $30,000 (£17,647), with just $5,975 (£3,515) raised as Wenn went to press.
On her page at act.buildon.org, Keough writes, "Help me build a primary school in Nepal through buildOn by making a donation. The process is fast, easy, and secure. I truly appreciate any support you can provide. It will benefit a great cause and help spread literacy...! Thanks so much for your generosity!"
Keough's actress pal Jaime King has given her backing to the charity campaign by sharing a link to the fundraiser on her Twitter.com page and writing, "Please help my dear (friend) Riley Keough raise 30k to build a school in Nepal with BuildOn."
The 25 year old is the daughter of Lisa Marie Presley and her ex-husband Danny Keough.