In the Arizona desert town of Prosperity, there is little to get excited about - not even the sparkling new shopping mall can bring energy to this lifeless place. But when a toxic spill oozes its way to a spider farm (local industry!), the spiders mutate into gigantic monsters and this sleepy town is in for a rude awakening. After eating up the dog, cat, and ostrich population, hundreds of hungry eight-legged beasts are ready to feast on the residents. It is now up to a love-struck miner (David Arquette), the best-looking sheriff since Suzanne Somers (Kari Wuhrer), her kids (Scarlett Johansson and Scott Terra), and an annoying ham-radio operator (Doug E. Doug) to save this who-really-cares little town.
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The film is expected to continue without Mendes' involvement.