The 42-year-old beauty - who has three daughters, Sam, seven, and six-year-old Lola, with the 46-year-old star, and adopted 10-month-old Eloise - was apprehensive when she shot her first scene of the former 'Two and a Half Men' actor's new forthcoming comedy show, despite being previously married to him for four years.
She said: ''I got a little nervous when we shot our first scene together because I looked up and I realised everyone was staring at us.''
Denise - who met Charlie on the set of 2001 comedy movie 'Good Advice' - still ''gets on well'' with the actor, and she insisted it was ''more weird for everyone else'' to see the pair filming scenes together.
She explained: ''I really think it's more weird for everyone else than it was for us. We get along well, and it's been a long time. We met working and we've worked together many times since then.
Denise - who has got back together with rocker Richie Sambora - hinted there could be some onscreen kissing with Charlie on 'Anger Management', and she admitted they had ''a lot of fun'' while shooting the show.
When asked if there is any onscreen embracing between the pair, she added to E!: ''Maybe. We had a lot of fun together.''