The Hole frontwoman was linked to the famed Lothario in 2006 when they were said to have spent a night together at a top hotel.
Now Kurt Cobain's widow has revealed Brand propositioned her and tried to get her into bed, but she turned him down because she didn't like his "musky" aroma.
She tells U.K. chat show host Alan Carr, "My favourite Russell Brand line (was) when we first were friends and he tried to hit on me, and nothing ever happened.
"You know, I'm female. He goes, 'I've had a lot of grand conservations darling but none of them have ever ended in an orgasm. Can we go in your room?'... He's got some good lines. And I said to Russell, 'You're too musky for me, man.'"