The 48-year-old supermodel stars in a commercial for Casamigos tequila - a brand owned by the actor and her husband Rande Gerber - in which her spouse catches her between the sheets with the 'Monuments Men' star and she admits the funny advert was inspired by a real-life encounter.
Cindy recalled: ''I woke up around midnight and snuck into the guest room and saw Rande laying facedown on the bed so I got on the bed and was like, 'Hey, babe, you gotta wake up', and 'babe' turned his head and it wasn't [Rande], it was George.
''I was shocked, and George, we were both so shocked, so we wandered downstairs, I went looking for Rande and was like 'George is in the guest bed, I just got in bed with him' and we all laughed.''
The couple - who have children Kaya, 12, and Presley, 14, together - own a house in Mexico next door to George Clooney and the supermodel admits they were initially hesitant to purchase the property because of their actor friend's bachelor lifestyle.
She told 'Entertainment Tonight': ''The two houses are practically adjoined, and I was like, 'Hmmmm we have kids, George is sometimes single, sometimes not single'. It could be great, or it could be a nightmare.''
However, Rande thought it would be ''fun''.
He said: ''I just thought it would be fun, we're always together anyway so why not have somewhere we could have all of us and our friends all be together.''
His new album Underneath It All is out now.