Cher's daughter Chastity Bono is undergoing surgery to become a man.
The writer, actress and musician - who confirmed she was gay in a magazine interview in 1995 - has been considering having the gender reassignment operation for a while, according to Bono's publicist Howard Bragman.
He reveals the gay rights activist's decision has been welcomed by her family and friends, and Bono - now known as Chaz - began the lengthy process to change genders after celebrating her 40th birthday in March (09).
Friends, including Bragman, have already started referring to her as a 'he'.
Bragman tells TMZ.com, "Chaz, after many years of consideration, has made the courageous decision to honour his true identity.
"He is proud of his decision and grateful for the support and respect that has already been shown by his loved ones. It is Chaz's hope that his choice to transition will open the hearts and minds of the public regarding this issue, just as his 'coming out' did nearly 20 years ago.
"We ask that the media respect Chaz's privacy during this long process."
Meanwhile, the Gay & Lesbian Alliance Against Defamation (GLAAD) has come out to salute Bono.
President Neil Giuliano says, "Chaz Bono's decision to live his life authentically represents an important step forward, both for him personally and for all who are committed to advancing discussions about fairness and equality for transgender people.
"Coming out as transgender is an extremely personal decision and one that is never made lightly. We look forward to hearing Chaz's story in his own words in the future."