The comic blasted the actress - who has been in a relationship with Brad Pitt, the ex-husband of the TV host's close pal Jennifer Aniston, since 2005 - during her stand-up comedy show in Newark, New Jersey on Friday (03.12.10), and mocked the brunette beauty for adopting three children from Cambodia, Vietnam and Ethiopia.
She ranted: "She's a homewrecker, she is. She can rescue as many babies from as many countries as she wants to. I don't f***ing believe you. She gives interviews, 'I don't have a lot of female friends.' Because you're a f***ing **** ... You're a f***ing b***h."
Though Angelina - who raises adopted Maddox, nine, Pax, seven, and five-year-old Zahara with Brad, as well as their biological kids, Shiloh, four, and two-year-old twins Knox and Vivienne - has always maintained she and her 'Mr. and Mrs. Smith' co-star never got romantically involved until after he split from Jennifer, Chelsea is not convinced.
One source said: "Chelsea hates Angelina and doesn't for one second buy that she is this good person rescuing children in need around the world. Everyone in Hollywood is scared to say what they really think about Angelina except Chelsea.
"She thinks Angie stole another woman's husband and should be called out on it."
Chelsea spent the recent Thanksgiving holiday in Mexico with Jennifer, and pals believe the outspoken presenter is a good influence on the former 'Friends' star.
The source added to gossip website PopEater: "Chelsea is the best thing to happen to Jen. Chelsea isn't afraid to tell Jen the truth even if it is painful. In the past Jen has made it clear that she doesn't want her friends talking about what went down between her, Brad and Angie.
"But Chelsea doesn't care. She thinks Angelina has used her kids to manipulate her image and gotten away with destroying a beautiful marriage. She's going to shout it from the roof tops whether Jen likes it or not."