Charlize Theron took aim at pal Chelsea Handler on the comedienne's late-night show in America on Wednesday (21May14) over her "cardboard" cupcake Christmas gift.

Theron was promoting her new film A Million Ways to Die in the West on Handler's Chelsea Lately show when the host asked her if she enjoyed the gluten-free treats she'd sent out to friends over the holidays.

The actress shot back, "I did not think we were gonna go there but if you want to discuss this on national television, then let's do this.

"I just think that if you are gonna send a gift, let it be enjoyable. Why send me a f**king cupcake with no sugar in it? What's the use...? It tastes like cardboard!

"And this was the ultimate test - I was in the middle of a fitting with a bunch of fashion people... They love skinny stuff... I had them taste it, and even they couldn't eat it... My dogs wouldn't even eat it. I couldn't get rid of the goddamn cupcakes in my kitchen!"

She added, "I think the gluten-free thing is bulls**t... I don't believe it and I think studies now recently just proved that it is bulls**t."

Theron didn't stop there - she also attacked Handler for only having gluten-free cake at her recent 39th birthday celebrations.

She said, "I think it's rude for you to only have gluten-free cake when none of us eat gluten-free, except you, who then didn't eat the cake."