Massey's gay character Will Horton will be recast after show bosses decided to replace the actor - and Sheen is far from happy.
In an angry tweet Sheen fired off on Friday (23Aug13), he wrote, "hey Days of Our Lives producers - newsflash you two dollar pig ph*****s: now your show Really sux!! you fired Chandler Massey??"
Massey, who won two Daytime Emmys for playing Will Horton, has taken the news better than his friend.
A statement he released on Friday reads: "I'm done. It's bittersweet. These four years have been so amazing. I've built a family here. I'm so grateful to everyone for these amazing four years."
Sheen is not unfamiliar with being fired - he was sacked from sitcom Two and a Half Men in 2011.