Richard Madeley and Judy Finnigan will broadcast their last ever Channel 4 show later today.
The married pair began presenting their show on ITV in 1988, before moving to Channel 4 in 2001.
Today's final show will involve a nostalgic look back at their history on terrestrial TV.
The couple announced last month that they are to move to a new multi-channel TV service called Watch, being launched in October.
Madeley, 52, and Finnigan, 60, became household names during their stint on ITV's This Morning.
Finnigan previously told UKTV: "When we announced our decision to leave our current television series after seven years, we were very touched by the number of people who told us how much they wanted to see us continuing making programmes together."