Vanessa and Jack are a loved up couple expecting their first child, with dreams of fixing up a dilapidated old house in New Orleans neighbourhood. Little do they know of the house's history and just why it hasn't been inhabited for so many years, but they are about to find it. A visit from their rather unconstructive new neighbour F'Resnel tells them that the building is nicknamed Maison de Sang - in English, House of Blood. Strange things begin to happen to the couple, with Vanessa displaying some extremely odd and disturbing behaviour leaving Jack with no choice but to call upon her psychiatrist and her sister Marjorie to help him find out what appears to be possessing her. Meanwhile, two exorcists from the Vatican are called to the house to do their own research into the demonic presence.
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