The 'Culture Club' singer will perform his 2010 collaboration 'Somebody to Love Me' with the famous producer for the first time at the annual festival, with Mark admitting he is ''really excited'' for the show.
The 'Uptown Funk' hitmaker said: ''I've put together this band so I'm really excited.
''And we've got Boy George so it's the first time we've been able to do 'Somebody to Love Me'.''
The 39-year-old producer also revealed he begged for his set to be moved from the Saturday night to Friday so he clashes with Foo Fighters, because he believed no one would want to see him if he was on at the same time as Saturday's headliner, Kanye West.
He revealed: ''We were originally meant to play on Saturday, but you just can't be on at the same time as Kanye, so I was like, 'Please move us!'''
Meanwhile, Mark - who wed model Joséphine de La Baume in 2011 - has also revealed he is working on a new album.
Speaking to Jo Whiley for Radio Times magazine: ''I don't know if I'm supposed to say any of this, but yeah, why not? I guess I put so much into this album, it's really important to me to try not to short-change any part of it.
''I don't want anything sort of half-baked, because I've done that in the past and been really disappointed with myself.''
There are currently five separate teams working on 'Game of Thrones' projects at HBO.
She's a big fan of the band and this week she got to perform with them.