The U2 frontman teamed with top designers Sir Jonathon Ive and Marc Newson to put together a collection of specially designed luxury items, from companies such as Hermes and Apple, for Jony and Marc's (Red) Auction at Sotheby's in Manhattan.
The event included a performance by Bono and Martin, who joined forces to sing a medley of U2's Beautiful Day and Lou Reed's Perfect Day, with the Coldplay star playing a custom-built red grand piano which was sold for $1.9 million (£1.3 million).
Other items featured in the sale included a storm trooper helmet from the Star Wars franchise signed by George Lucas which sold for $245,000 (£163,333).
The auction was attended by more than 1,000 guests including Harrison Ford, Meg Ryan, Courtney Love and Hayden Panettiere, and it raised around $13 million (£8.7 million) for Global Fund to Fight Aids, Tuberculosis and Malaria.
The final total came in at around $26 million (£17.3 million) after executives of the Bill and Melinda Gates Foundation agreed to double the sales figure.