The legendary rock band, fronted by Ozzy Osbourne, have confirmed they'll perform on the second day of the annual music festival on Saturday, 11 June at Donington Park, Leicestershire, as part of their final ever 'The End' tour.
In a statement, Ozzy, 66, said: ''Download is my absolute favourite summer festival. It's always like coming home. See you all there!''
The gig is set to be ''their biggest and most mesmerising production to date.''
It was previously announced Iron Maiden will close the event on Sunday, 12 June, their only UK show next year, but the third and final headliner has yet to be announced.
The band will fly in to East Midlands Airport on their Boeing 747-400 jumbo jet Ed Force One, piloted by Bruce Dickinson and carrying band, crew, stage production and equipment over 55,000 miles around the world, visiting 35 countries on 'The Book Of Souls World Tour'.
Bruce recently said: ''Download is a very special place for us. Not just because it's always great to play on home turf but because there's a truly unique vibe there, it's the very heart of England and of Metal, so a fitting place for Iron Maiden!
''The crowd is always fiercely passionate and the whole band feeds off that famous Donington energy. We aim to deliver a really memorable show for our fans to close the 2016 Festival.''
American Thighs was released on this day in 1994.