The Dutchman was crowned the top record spinner by editors at Dj Mag during a ceremony in Amsterdam, Netherlands.
Tiesto placed second, Avicii is third, Guetta - the 2011 winner - fell to fourth place, and Deadmau5 rounded out the top five.
Van Buuren says, "2012 opened new doors. David being No.1 last year, the popularity of Avicii, Swedish House Mafia and Afrojack, for dance music, it's amazing. It was great that David got it last year, to show dance music is evolving and it's still exciting.
"Being No.1 again feels fantastic - there's so much love out there. I'm so thankful for it."