Based on the novel by Michael Crichton, Sphere concerns a team called the ULF team (Unknown Life Form). These people, hand picked by Norman Johnson (Dustin Hoffman) during the cold war, are a team designed to make contact with alien life. On it are a mathmatician (Samuel L. Jackson), an astrophysicist (Liev Schrieber), a biologist (Sharon Stone), and a shrink who didn't take the whole thing seriously and picked people to be at each other's throats (Dustin Hoffman).
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He's certainly not wasting his newfound talents.