Lindsay and Jenny (Williams and Yennie) are naive Americans driving through Germany when they get lost on the way to a nightclub. Disoriented in the woods, they find the home of Dr Heiter (Laser), who quickly drugs them so he can use them for an experiment he previously tried on his dogs, namely sewing them together with a third victim (Kitamura) into a three-part "centipede". Lindsay wriggles out of her bonds before the operation, but can she escape? And what will Heiter do to the cops (Leupold and Blankenstein) who come snooping around?
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In years past Dr Heiter had been one of the best surgeons of his kind, separating siamese twins was his speciality. Since his retirement, Dr Heiter spent most of his time at home. When two American friends who're on a roadtrip through Europe find themselves in a broken-down car, the only choice is to get out and walk.
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