The 44-year-old actor attended the World Meeting of Families in Philadelphia on Saturday (26.09.15) and joked he hoped God had a ''sense of humour'' about his appearances opposite the foul-mouthed bear in the raunchy comedies.
After a young soloist, 14-year-old Bobby Hill, performed at the event, Mark took to the podium and said: ''That was truly the voice of an angel. But then he whispered in my ear that he loved the movie 'Ted'. And I told him that was not appropriate for a boy of his age.
''Holy Father please forgive me. I've always hoped that the good Lord has a sense of humour when it comes and pertains to many of the movies that I've made.''
The pope organised his six-day visit to North and Central America, which concluded yesterday (27.09.15), to coincide with the event.
Mark - who has sons Michael, nine, and Brendan, seven, and daughters Ella, 12, and Grace, five, with wife Rhea Durham - has previously spoken of how important his Catholic faith is to him.
He said: ''Being a Catholic is the most important aspect of my life.''