The Grease star is launching Pink and Blue for Two, which takes its name from a campaign founded by her nephew Emerson Newton-John urging men and women to support each other by attending breast and prostate cancer screenings together.
The campaign will receive 10 per cent of the proceeds from the wine, and a further 10 per cent will go to Newton-John's own cancer foundation.
She tells FOX411, "(The wine is a) Merlot I love and I actually chose it. They sent me a lot of samples and I chose that one."
The Physical hitmaker knows from personal experience the difficulty of fighting cancer, having battled the disease in 1992, and she is keen to support the campaign, adding, "It's fantastic that there's so much attention put on breast cancer but the guys need a little love too."