The Boardwalk Empire star received a prize at the Made in New York Awards for his contribution to the city's arts industry, and he was handed the trophy by De Blasio.
Buscemi took the opportunity to poke fun at the mayor and lambast his tough policies on motorists, joking that he had been due to film an appearance in a video round-up of the nominees, but missed his slot due to the low speed limits.
Buscemi said, "I was going there (to film) and I was driving 25 miles per hour and I was late," before adding "I was safe. And that's a good thing."
Other honourees at the event included Neil Patrick Harris, comedian Louis C.K., actress Rosie Perez, and Sex and the City producer Jane Raab.