The actress - who plays Mercedes Jones in the musical drama series - says it was an incredible experience to honour the flamboyant pop star's music on the series and one she will never forget.
She said: "There are so many highlights, but my favourite moment has to be doing Lady Gaga! Those costumes were amazing. I felt like a superhero."
In the tribute episode - which aired in the US in May - a number of Gaga's songs were recreated and several members of the cast wore some of her most iconic outfits, including Lea Michele (Rachel Berry) in her version of Gaga's Kermit the Frog dress and Heather Morris, who plays ditzy cheerleader Brittany, in the infamous lobster head-dress.
Another memorable moment in 2010 for Amber was attending the Emmy Awards in August and getting to walk the red carpet in a glamorous dress.
She said: "I really loved my dress at the Emmys - I felt it was the first time I got to really make a statement on the red carpet. And I designed that dress."
'Glee' won over 10 awards at the prize-giving ceremony, including Outstanding Lead Actor in a Comedy Series for Matthew Morrison, Outstanding Lead Actress in a Comedy Series for Lea Michele and the prize for Outstanding Comedy Series.