Actresses Allison Janney, Blythe Danner and AnnaLynne McCord have teamed up for a public service announcement (Psa) heralding "the beginning of the end of Aids".
Jason Ritter, Melanie Lynskey and Edward James Olmos also appear in the I Predict clip, which features stars hazarding guesses about what the future will hold.
Olmos jokes, "By 2015, fax machines will make a huge comeback!" while Lynskey deadpans, "There will be no more kittens on YouTube."
Six Feet Under star Richard Jenkins then declares, "(By 2015) we will see the beginning of the end of Aids," with rapper/actor Ice-T agreeing, "That we can do."
Viewers are asked to show support for the I Predict campaign, part of U2 rocker Bono's One charity to end the Aids epidemic, by sharing the video on their social networking page.