The liberals only garnered 25 of the necessary 41 votes required to delay the appointment, leaving the actors fearful for their traditionally liberal party's future.
Baldwin targets the growing conservative sentiment among officials, according to the New York Daily News.
He says the problem is "chicken-s**t Democrats in the Senate. We have a bunch of budding Zell Millers (Georgia senator) down there. I loathe and despise him on a daily basis."
However, Streep - whose nephew is going to war in Iraq - has sunken into a depression over corruption in US politics and the war in Iraq.
Streep says, "I'm so demoralised. I want a candidate to come out of nowhere and have no conflicts. I want major campaign reform. I want Jesus to come back and throw the money lenders out."
"Everybody in the administration should have a kid in that conflict. Then they'll know how they feel about it."