Al Pacino and Charlize Theron are set to reunite on the big screen in a bid to save the world.

The Oscar-winners, who first teamed up in 1997's THE DEVIL'S ADVOCATE, will head an all-star cast in THE SIGN.

Ben Kingsley, Kris Kristofferson, Michael Keaton and Harry Connick Jr are also in negotiations to appear in the apocalyptic thriller.

According to the Fathom website, the film follows the efforts of a young couple trying to infiltrate the ranks of a cult to rescue a kidnapped Jewish professor and prevent religious zealots from ending the world.