The moviemaker's 2009 comedy, starring Helms alongside Bradley Cooper, Zach Galifianakis, Justin Bartha and Heather Graham, was a critical and commercial success, making a massive $467 million (£311 million) at the worldwide box office and winning a Golden Globe award for Best Picture - Musical or Comedy.
The cast is currently filming a follow-up, which will see the characters travel to Thailand for a wedding, but Helms is adamant they won't be reprising their roles a third time.
When asked about the possibility of another sequel, he tells the Los Angeles Times, "I doubt it. I don't think Todd would let that happen... I would hope that The Hangover kind of has a dignified legacy, if that makes any sense."
Continue reading: Helms: 'There's No Hangover 3'
Kesha MOST SCROBBLED ARTIST OF 2010
In the year that KESHA launched her music career, she became the most scrobbled artist on Last.fm in 2010 with over 15 million plays. The singer broke onto the music scene with her album 'Animal' back in January and has seen chart success with singles including, 'Blah Blah Blah' and 'Tik Tok', she also featured on Flo Rida's hit 'Right Round'
Other acts in the global top 10 include Mumford And Sons, Arcade Fire, The National, Katy Perry, Rihanna, 30 Seconds to Mars, GORILLAZ And Eminem who is the only performer to make an appearance in the chart for two years running.
All the albums in the list were released between 1st October 2009 and 1st November 2010. Last.fm monitor users listening habits through software installed on the user's computer, they record over 43 billion tracks a year listened to by over 40 million users.
Continue reading: Kesha Most Scrobbled Artist Of 2010
The Dave Matthews Band has returned to the top of the U.S. album chart with their fifth consecutive number one debut.
Big Whiskey and the GrooGrux King claims the third biggest opening week in 2009, behind albums by Eminem and U2.
Eminem's Relapse slips to number two and rockers 311 debut at three on the new countdown with Uplifter. Green Day's 21st Century Breakdown and Lady GaGa's The Fame round out the top five.
The new top 10 also features debuts from Sammy Hagar's new supergroup Chickenfoot, at six, and Taking Back Sunday at seven.
Continue reading: Dave Matthews Band Score Fifth Number One Album In A Row